Professor Pablo Moscato
Professor at the School of Electrical Engineering and Computing, University of Newcastle, Australia
Founding Co-Leader of the INFORMATION-BASED MEDICINE PROGRAM of the Hunter Medical Research Institute
Category of Humanitarian Benefit: Health and Medical, Knowledge Sharing
Biography/Background of Nominee: 30 years ago, Pablo Moscato came to Caltech as a ROTARY SCHOLAR from La Plata, Argentina. He was a full-time visiting Graduate Student in Physics from Sept. 1988-Oct. 1989. Before coming to Caltech, he received his degree in Physics from the Universidad Nacional de La Plata, in La Plata, Argentina in 1987. He received his PhD in Electrical Engineering/ Automation from the Universidade Estadual de Campinas, in Campinas Brazil in 2001. In 2002 Pablo was hired as an instructor at the University of Newcastle, Australia and soon became the FUNDING DIRECTOR of the Newcastle Bioinformatics Initiative (2002-2006). He then became the FOUNDING DIRECTOR of the Centre for Bioinfomatics, Biomarker Discovery and Information-based Medicine (2006-2015.) He is Co-Editor of 3 books with a 4th to be published in 2018; has 31 book chapters; 98 peer reviewed journal papers and 110 peer reviewed conference papers. Pablo has returned to Caltech 2 times, the last in September 2018 where he gave 2 papers and participated in a 2 day "Caltech-Swinburne Data Science Workshop". He then presented a paper at the first IEEE conference in Laguna Hills Ca. entitled, "Symbolic Regression Modeling of Drug Responses." This summer, Pablo helped sponsor 2 Caltech first year students to have internships in mathematics at Newcastle, Australia and he expects to annually be able to offer 4 internships to Caltech students.
Project Name and Description: Professor Moscato's RESEARCH INTEREST is in Data Science-Computational Sciences Computational Systems Biology in Health and Disease - Applied Computer Science - Application and development of state-of-the-art mathematical models and computer algorithms for the most challenging problems in biology and biotechnology research with emphasis on uncovering the molecular basis of different cellular phenotypes and diseases. While at Caltech in 1988 as a ROTARY SCHOLAR, he was the world's first person to coin the term "memetic algorithms" and his published work on this has created a whole new field of mathematics that has gained worldwide reputation with over 10,000 citations and this work continues to get several citations every week.
Humanitarian Benefit: Using data of the Alzheimer's Disease Neuroimaging Initiative, Pablo led the team that was the world's first in identifying a panel of proteins that allow to have a longitudinal test that predicts the onset of the disease several years in advance. He also lead the bioinformatics work that allowed them to produce the first interactive map of RNA stability, including long non-coding RNAs. He also introduced a unifying hallmark of cancer based on the changes of Information Theory quantifiers. He proved the validity of the power of Information theory driven methodology by applying the technique to the identification of Alzheimer's Disease biomarkers; He identified new Multiple Sclerosis susceptibility loci on chromosomes 12 and 20; he has also developed several other bioinfomatic activities including the first method to distinguish childhood absence epilepsy from controls by the analysis of their background EEG.